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- W2376945758 abstract "Objective:To investigate the expression of IL-4 and IL-13 receptors in the renal proximal tubular epithelial cells(HK2) and effects of IL-4 and IL-13 on HK2.Methodology:The expressions of IL-4 and IL-13 receptors were studied by RT-PCR and immunofluorescence.After being treated with 10ng/ml,50ng/ml or 100ng/ml IL-4 and IL-13 for different times(12h,24h,48h),the changes of RANTES expression on HK2 were observed by confocal microscopy.In order to understand the underlying mechanisms of IL-4 and IL-13 effect on tubular epithelial cells,the activity of JAK-STAT 6 signal pathway was analyzed by measuring the extent of phosphory-lation of JAK-STAT 6 using western blot.Results:The expression of IL-4 and IL-13 receptors mRNA and proteins were detected in HK2.IL-4 and IL-13 induced the increase of RANTES expresssion in a dose and time-dependent manner.HK2 treated by 100ng/ml IL-4 and 50ng/ml IL-13 for 48 hours stimulated the hyperexpression of RANTES.Western blot demonstrated phosphorylation of JAK-STAT 6 in HK2 upon incubation with IL-4 and IL-13.Leflunomide,which is specific inhibition of JAK-STAT 6,could block the effect of IL-13 on HK2.Conclusion:HK2 expressed IL-4 and IL-13 receptor,and IL-4 and IL-13 stimulated hyperexpression of RANTES.The effects of IL-4 and IL-13 above were related with JAK-STAT 6 signal pathway." @default.
- W2376945758 created "2016-06-24" @default.
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- W2376945758 date "2009-01-01" @default.
- W2376945758 modified "2023-09-28" @default.
- W2376945758 title "IL-13 and IL-4 receptors expression mediat the injury of tubular epithelium cells" @default.
- W2376945758 hasPublicationYear "2009" @default.
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