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- W2376951567 abstract "Objective On the basis of the lasted clinical experience,our group will discuss the treatmented mechanism of Chinese herb kang-xian-er-hao(KXEH) ameliorate hepatic cirrhosis. Methods Male wistar rats were divided into five groups,excepted for normal group N,the remnant four groups were all given intraperitoneal injection of porcine serum((0.5) ml/time,2 times/week,total 12 weeks).In KXEH early treatment group B,the rats were fed with KXEH by gavage,1 g/100 g,once a day at the third week.In KXRH late treatment group C,the rats were fed with KXEH by gavage,1 g/100 g,once a day at the ninth week.In γ-interferon treated group D the rats were subcutaneous injection γ-interferon((0.1) million) every day at the ninth week.The model group A and normal group N were fed with the same amount of saline by gavage.The rats were killed at the end of the twelfth weeks,the formation of liver fibrosis was observed with HE stain and Masson stain.The expression of Smooth muscle actin(SMA) was observed by immunohistochemistry.As well as SMA,collagen Ⅰ、Ⅲ mRNA and Smad3 mRNA,which is TGF-β1 downstream signal,were detected in liver samples with RT-PCR assay. Results In KXEH treated group B and C,the body weight was heavier,the size of liver and spleen was smaller and the ratio of liver weight/body weight and spleen weight/body weight was decreased compared with the model group A(P(0.05)).Upon pathological examination and with HE stain and Masson stain assay,the KXEH treated groups had some reverse effects on the rat's fibrotic liver.In group B the grade of liver fibrosis was decreased apparently compared with the model group A(P(0.05)). On the rat's fibrotic liver,the expression of type-Ⅰ,type-Ⅲ collagen SMA and Smad3 mRNA was markedly reduced in the KXEH treated group B as compared with the model group A(P(0.05)).Moreover the expression of SMA through the immunohistochemistry assay was obviously decreased in the KXEH treated groups.A high relativity was found between the expression of Smad3 mRNA and the expression of typeⅠ,type-Ⅲ collagen mRNA SMA(r=(0.890)).Conclusions KXEH has a good reverse effect on the the rat's fibrotic liver that was prepared by immune injury.It seems the reverse effect of KXEH is in part due to the suppression of the hepatic stellate cell(HSC) proliferation and inhibit the expression of Smad3,which is hepatic fibrotic correlative cytokine TGF-β1 downstream signal." @default.
- W2376951567 created "2016-06-24" @default.
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- W2376951567 date "2005-01-01" @default.
- W2376951567 modified "2023-09-26" @default.
- W2376951567 title "Effect of Kang-qian-er-hao on experimental hepatic fibrosis in rats" @default.
- W2376951567 hasPublicationYear "2005" @default.
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