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- W2376959098 abstract "OBJECTIVE:To evaluate whether concurrent exposure of human hepatocellular carcinoma cells SMMC-7721 to TRAIL with chemotherapeutic agents or hyperthermia will increase anticancer effects. METHODS: Four chemotherapeutic agents such as cisplatin, hydroxycamptothecin, mitomycin C and gemcitabine were applied. MTT assay was used for quantitative evaluation of proliferation of SMMC-7721 and cytotoxicity of anticancer drug. Flow cytometric analyses were used for the assessment of apoptosis rates after the treatment. RESULTS: The combination of the two treatments induced significantly higher apoptosis and cytotoxicity than exposure to TRAIL or chemotherapeutic agents alone, but the combination of TRAIL and hyperthermia did not show synergistic effect. CONCLUSIONS: While both TRAIL and chemotherapeutic agents can individually induce apoptosis and anti-proliferation effect, they may offer synergistic benefits when used concurrently." @default.
- W2376959098 created "2016-06-24" @default.
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- W2376959098 date "2006-01-01" @default.
- W2376959098 modified "2023-09-23" @default.
- W2376959098 title "Research on combination of TRAIL with chemotherapy or hyperthermia against hepatocellular carcinoma cell line SMMC-7721 in vitro" @default.
- W2376959098 hasPublicationYear "2006" @default.
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