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- W2376965319 abstract "Objective: To explore the correlation between the content of HBV large envelope protein(HBV-LP) and the HBV-DNA load in hepatitis B patients,and to discuss the clinical application of HBV-LP in hepatitis B patients HBeAg negative.Methods: Serum HBV-LP and HBVM were detected by using ELISA,and the HBV-DNA was quantitively detected by using real time polymerase chain reaction(RT-PCR).Results:(1)In 405 serum samples of the patient with HBV infection,positive rate of HBV-LP and HBV-DNA were 75.06% and 70.12%.(2)The level of HBV-LP and HBV-DNA copies performed a nice positive correlation(r= 0.944,P0.05).(3) No significant difference of positive rate was found between HBV-LP(93.67%) and HBV-DNA(88.61%) in 158 HBeAg positive serum samples,no significant difference of positive rate was found between HBV-LP(63.16%) and HBV-DNA(58.30%) in 247 HBeAg negative serum samples.(4) Significant difference of positive rate was found between HBV-LP(83.45%) and HBeAg(49.30%) in 284 serum samples with HBV-DNA positive.Conclusion: HBV-LP was a sensitive index in reflecting hepatitis B virus replication level,especially to the HBeAg negative chronic hepatitis patients." @default.
- W2376965319 created "2016-06-24" @default.
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- W2376965319 date "2010-01-01" @default.
- W2376965319 modified "2023-09-23" @default.
- W2376965319 title "Correlation between content of HBV large envelope protein and HBV-DNA load" @default.
- W2376965319 hasPublicationYear "2010" @default.
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