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- W2376965730 abstract "Objective To explore effects of two different recombinant human growth hormone (rhGH) on GH-deficient (GHD) children.Methods Out of the two groups of GHD children,one group (including 19 patients) was on a weekly rhGH dose of 0.7 IU/kg body weight which was divided in 7 days (each injection dose of 0.1 IU/kg body weight),and the other group (including 18 patients) was on a weekly rhGH dose of 0.5 IU/kg body weight which was divided in 5 days (each injection dose of 0.1 IU/kg body weight).All the patients were treated with rhGH for at least 6 months,and the main axiological variables were observed including height gain,height velocity,height SDS,bone age and the level of serum insulin-like growth factor-Ⅰ and insulin-like growth factor binding protein-3.Results Both groups had significantly accelerated the growth of GHD children.Within the 6 months treatment,children in both groups gained significant increased in height,height velocity and height SDS.The same group had significant differences during the 6 months.But there were no significant differences between the two groups.Conclusions GHD children treated with GH 5 days weekly had the same effect of promoting growth as the conventio-nal.Because of the heavy economical burden of GH in China,treatment with 5 days weekly could prolong the duration of the treatment,and at same time,5 days treatment decrease the pain of injection.So the 5 days treatment is high cost-benefit,fit for our country and worthy of spread." @default.
- W2376965730 created "2016-06-24" @default.
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- W2376965730 date "2007-01-01" @default.
- W2376965730 modified "2023-09-23" @default.
- W2376965730 title "Effects of Two Different Recombinant Human Growth Hormone Doses Treatment on Growth Hormone-Deficient in Children" @default.
- W2376965730 hasPublicationYear "2007" @default.
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