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- W2376973893 abstract "AIM:To study the current density and function of L calcium channel in cells from the epicardial border zone of the 1 week and 2 month infarcted rabbit hearts. METHODS:Rabbits were infarcted by ligation of the left anterior descending coronary artery,1 week(PMI 1 wk) and 2 month(PMI 2 mo) later, I Ca L was recorded using whole cell patch clamp techniques from infarcted heart and compared with the I Ca L from the noninfarcted heart(Con). RESULTS:Peak I Ca L current density(at 0 mV) was significantly reduced in PMI 1 wk (3.5±0.9 pA/pF, n =6)compared with Con group (5.6±1.5 pA/pF, n =10), P 0.01. However, 2 month after the occlusion,the peak I Ca L density in PMI 2 mo(4.8±1.5 pA/pF, n =11) was not significantly different from that of the Con group, although there was slight reduction in it . V 0.5 of the availability curve was shifted significantly in the hyperpolarizing direction in PMI 1 wk (-26±7 mV, n =6) compared with that of the Con group (-13±4 mV, n =8), P 0.05. V 0.5 was also shifted in the hyperpolarizing direction in PMI 2 mo(-21±6 mV, n =8) compared with that of the Con group,although this shift was not significant, P 0.05. CONCLUSION: I Ca L was reduced,and its kinetics was altered in myocytes of the infarcted zone. 2 month after the occlusion,the depressed I Ca L returned to nearly normal, suggesting the presence of reverse remodeling." @default.
- W2376973893 created "2016-06-24" @default.
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- W2376973893 date "2003-01-01" @default.
- W2376973893 modified "2023-09-25" @default.
- W2376973893 title "Alteration of L-calcium current in ventricular myocytes from infarcted rabbit hearts" @default.
- W2376973893 hasPublicationYear "2003" @default.
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