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- W2376976587 abstract "Aim To investigate changes of Th1/Th2 cytokines in Lungs at different developmental stages of rat silicosis models and to study the relationships between Th1/Th2 cytokines and the pathogenesis of silicosis.Methods Thirty healthy male SD rats were randomly divided into the silica exposure group and the control group.One ml silica suspension(40 g·L-1) was administrated via intratracheal instillation once while equal amount of saline was instilled to the rats of control group.Animals were sacrificed at the 1st,7th,14th,21st,28th,and 35th day after instillation,and the samples of lung tissues were collected.The expression of IFN-γ and IL-4 was observed by use of immunohistochemistry method and quantitative analysis of protein expressions by image analysis system.Results In early stage of experiment(1,7,14,21 d),the levels of IFN-γ in lungs of silicotic rats obviously increased than those in control group(P0.05),the levels of IL-4 significantly decreased(P0.05).In later stage(28,35 d),the levels of IFN-γ in lungs of silicotic rats had no obvious difference with control group(P0.05),and the levels of IL-4 were significantly increased(P0.05).Conclusion In early stage of silicosis,cell-mediated immunity by Th1 cytokines was dominant.But humoral-immunity enhanced In later stage,Th2 cytokines were increasingly secreted and humoral-immunity enhanced." @default.
- W2376976587 created "2016-06-24" @default.
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- W2376976587 date "2010-01-01" @default.
- W2376976587 modified "2023-09-23" @default.
- W2376976587 title "Changes and significance of Th1/Th2 cytokines in lungs of experimental silicotic rat" @default.
- W2376976587 hasPublicationYear "2010" @default.
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