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- W2376977079 abstract "Objective To investigate the correlationship between apolipoprotein E(ApoE) gene polymorphism and carotid artery sclerostenosis.Methods The polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP) was used to analyze the gene polymorphism of ApoE in 25 carotid artery sclerostenosis patients and 25 healthy age-matched controls.Results Compared with the control group,an increased frequency of ApoE e4 allele(P0.01) and decreased ApoE e3 allele frequency(P0.05) were found in carotid artery sclerostenosis group.There were significant increase in e3/e4 and e4/e4 allele frequency,and e4 allele was in particular.Three ApoE genotype groups were defined:ApoE2(e2/2+e2/3),ApoE3(e3/3),ApoE4(e3/4+e4/4),the degree of sclerostenosis of the ApoE was higher than the other two groups.Conclusions ApoE polymophysims may be associated with carotid artery sclerostenosis.ApoEe4 allele may be a risk factor for the carotid artery sclerostenosis." @default.
- W2376977079 created "2016-06-24" @default.
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- W2376977079 date "2008-01-01" @default.
- W2376977079 modified "2023-09-26" @default.
- W2376977079 title "Correlationship between the polymorphism of apolipoprotein E and carotid artery sclerostenosis" @default.
- W2376977079 hasPublicationYear "2008" @default.
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