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- W2376981883 abstract "In order to prepare the targeting drugloaded system,magnetic chitosan-5-Fu nanoparticles(MCN-Fu) were prepared by using 5-Fu as a model drug,Fe_3O_4 nanoparticles as the core and glutaraldehyde as cross-linking agent under ultrasonic treatment.TEM images show that MCN-Fu are spherical shape with diameters ranged from 50 nm~ 60 nm.The IR results indicate there is a strong molecular interaction between 5-Fu and chitosan.The drug content,in vitro release and magnetic properties of MCN-Fu were investigated by UV-vis spectrum.The results indicate that the drug content is(21.3%),and accumulative release percentage in phosphate buffer(pH=(7.2)) solution is(67.6%) in 30 h,the drug release rate is found decreased and they can in some degree reduce initial burst.MCN-Fu have good magnetic properties and target effect." @default.
- W2376981883 created "2016-06-24" @default.
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- W2376981883 date "2007-01-01" @default.
- W2376981883 modified "2023-09-24" @default.
- W2376981883 title "Preparation and in Vitro Release of Magnetic Citosan-5-Fluorouracil Nanoparticles" @default.
- W2376981883 hasPublicationYear "2007" @default.
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