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- W2376985404 abstract "Aim: To investigate the expressions of Na+-Ca2+ exchanger isoform NCX3 mRNA and protein in the dentate gyrus, CA1, CA3 regions by hippocampus of lithium-pilocarpine induced epileptic rat. Methods: The models of epilepsy were established by injecting pilocarpine and lithium. The NCX3 mRNA and protein were quantitatively analyzed at different time by using in situ hybridization and immunohistochemistry. Results: Expression of NCX3 mRNA in the hippocampus had significant decreases at 6 h, 12 h and 24 h after seizures, then increased slowly to normal level. However, at 30 d and 60 d, a second dramatic decrease was found in NCX3 mRNA expression. The change tendency of NCX3 protein was similar to NCX3 mRNA, except the protein did not increase at 6 h. Conclusion: The decreased expression of NCX3 in hippocampus might increase the overloading of free intracellular calcium and change the excitability of hippocampal neurons to induce seizures." @default.
- W2376985404 created "2016-06-24" @default.
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- W2376985404 date "2007-01-01" @default.
- W2376985404 modified "2023-09-28" @default.
- W2376985404 title "Altered Expression of Na~+-Ca~(2+) Exchanger Isoform NCX3 mRNA and Protein in Hippocampus of Temporal Lobe Epileptic Rat" @default.
- W2376985404 hasPublicationYear "2007" @default.
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