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- W2377013306 abstract "AIM: To study the influence of glucose or insulin at different concentrations on the expression of adiponectin in cardiomyocytes. METHODS: Myocardial cells were isolated from the hearts of neonatal Sprague-Dawley rats and primarily cultured.The cells stimulated with glucose at concentrations of 5.5,20,25,30,and 50 mmol/L respectively were divided into 5 groups and a hypertonic control group was set up.The cells treated with insulin at concentrations of 0,10-10,10-9,10-8,10-7 and 10-6 mol/L were also divided into 6 groups.The mRNA and protein levels of adiponectin(APN) were determined by RT-PCR and Western blotting 48 h after the intervention with glucose or insulin. RESULTS:(1) The expression of adiponectin decreased with the elevation of glucose concentration at the doses lower than 30 mmol/L(P0.05).When higher than 30 mmol/L,the expression of adiponectin didn't change significantly.The osmotic pressure did not affect the adiponectin expression in cardiomyocytes.(2) The expression of adiponectin decreased with the elevation of insulin concentration at the doses lower than 10-7 mmol/L(P0.05).When higher than 10-7 mmol/L,the expression of adiponectin didn't change significantly. CONCLUSION: The expression of APN decreases with the elevation of glucose or insulin concentrations within a certain range of dosage." @default.
- W2377013306 created "2016-06-24" @default.
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- W2377013306 date "2011-01-01" @default.
- W2377013306 modified "2023-09-23" @default.
- W2377013306 title "Influence of glucose and insulin on expression of adiponection in neonatal rat cardiomyocytes" @default.
- W2377013306 hasPublicationYear "2011" @default.
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