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- W2377014719 abstract "Objective: To establish a rat animal model of trigeminal neuralgia for the basic research on the mechanism and therapy.Methods: Rats were randomly divided into two groups: the operation group and the sham operation group.In the operation group,an unilateral chronic constriction injury(CCI) was produced by placing loose chromic gut ligatures around the infraorbital nerve(ION).In the sham operation group,the ION was only exposed using the same procedure but not ligated.The behavioral reactions and the mechanical response threshold(pain threshold) were observed at different times after operation.Results: An allodynia to mechanical stimulation on the territory of ligated ION was found from the 2nd to the 8th week after operation in the operative group.There was significant difference(P0.01) in pain threshold,compared with the pre-operation and the contralateral side in the operation group and the sham-operation group.The thresholds started to increase gradually from the 4th week and reached the original level on 12th week after operation.Conclusion: CCI-ION results in experimental trigeminal neuralgia,which can be relieved by decompression." @default.
- W2377014719 created "2016-06-24" @default.
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- W2377014719 date "2010-01-01" @default.
- W2377014719 modified "2023-09-26" @default.
- W2377014719 title "Establishment of rat animal model for trigeminal neuralgia following chronic constriction injury" @default.
- W2377014719 hasPublicationYear "2010" @default.
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