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- W2377014952 abstract "Objective To study the pharmacokinetics of cefoperazone and sulbactam (1∶1) in healthy adult and old people. Methods Of the 44 volunteers enrolled, 24 were adults(male 12, female 12), 20 were male old people. Volunteers were iv given 1g cefoperazone and 1g sulbactam q.d, for 3 consecutive days. On day 4, blood samples were taken at different time intervals after the first administration.Serum was separated and HPLC methods were used to determine the concentrations of cefoperazone and sulbactam in serum.Results Sulbactam:at steady state, the paremerters for male adults, female adults and old people were as follows:CL were (30.6±5.2),(29.3±4.3),(13.7±4.9) L·h -1;V_d were (49.7±21.2),(58.8±23.1),(28.7±15.7) L;t_ 1/2 were (1.2±0.5),(1.4±0.4),(1.4±0.4) h; C_ max were (27.9±4.8),(26.5±4.3),(54.7±19.9) mg·L -1;AUC were (33.7±6.74),(34.7±4.64),(81.8±28.4) mg·h·L -1 respectively. Cefoperazone: at steady state , the paremerters for male adults, female adults, and old people were as follows: CL were (5.7±1.2),(4.8±1.3),[LM]( 4.2±1.2) L·h -1;V_d were (11.7±2.7),(11.7±4.6),(12.8±3.8) L; t_ 1/2 were (1.5±0.5),(1.7±0.4),(2.2±0.6) h; C_ max were (89.4±10.7),(110.8±24.7),(102.0±15.3) mg·L -1;AUC were (182.3±49.6),(224.7±60.7),(256.3±72.0) mg·h·L -1 respectively. Conclusion There were significant differences in pharmacokinetic parameters of sulbactam between adults and old people. While the differences in the pharmacokinetic parameters of cefoperazone were not significant in these two groups. The sexual difference between male and female adults was not significant either." @default.
- W2377014952 created "2016-06-24" @default.
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- W2377014952 date "2007-01-01" @default.
- W2377014952 modified "2023-09-26" @default.
- W2377014952 title "Pharmacokinetics of sulbactam/cefoperazone (1∶1) in healthy adult and old people" @default.
- W2377014952 hasPublicationYear "2007" @default.
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