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- W2377023356 abstract "Four different diselenide-crosslinked polyethylenimine(PEISeSe) were successfully prepared by changing the dosage of cross-linker and reaction time. The influence of cross-linking level on the DNA condensation,proton buffer capacity and transfection efficiency were investigated. The results indicated that the proton buffer capacity of PEISeSe was reduced with cross-linking level. All of the polycations could efficiently condense DNA into spherical particles with diameter of 150 nm at m(PEISeSe)/m(DNA) = 8. Moreover, diselenide bonds were easily cleaved in the presence of DTT. Cell culture results indicated that by adding chloroquine to exclude the limitation of lysosome escape,PEISeSe showed decreased cell cytotoxicity and efficient transfection. The proper reason was that the intracellular cleavage of diselenide bonds facilitated DNA release and nuclear entry. The diselenide-crosslinked polycations had promising potential in redox-sensitive gene delivery." @default.
- W2377023356 created "2016-06-24" @default.
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- W2377023356 date "2014-01-01" @default.
- W2377023356 modified "2023-09-28" @default.
- W2377023356 title "Stimulus-responsive Diselenide-crosslinked Polyethyleneimine as Gene Vector" @default.
- W2377023356 hasPublicationYear "2014" @default.
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