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- W2377027436 abstract "Objective It is to observe the effect of aminoguanidine on cell apoptosis induced by acute pulmonary embolism in rats. Methods The rats were randomly divided into control group, model group and treatment group. Experimental pulmonary embolism models of rats were made with injection of rat clots in vitro into right ventricle of model group and treatment group with improved vessel method. Treatment group and model group were immediately given abdominal cavity injection of aminoguanidine and normal saline respectively. Control group were only given blood serum with vessel. The rats were killed at 1h after pulmonary embolism and the lungs were gotten quickly. The cell apoptotic percentage was mensurated with FCM. Caspase-3 protein was measured with immunohistochemical method. Results Apoptotic percentage rose and the number of Caspase-3 protein positive-staining cells increased obviously. After given aminoguanidine, the percentage lowed and the number deceased obviously. Conclusion Aminoguanidine can lower the apoptotic percentage and the expression of Caspase-3 protein after acute pulmonary embolism, and has protection action on rats with acute pulmonary embolism." @default.
- W2377027436 created "2016-06-24" @default.
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- W2377027436 date "2005-01-01" @default.
- W2377027436 modified "2023-09-24" @default.
- W2377027436 title "Effect of aminoguanidine on cell apoptosis induced by acute pulmonary embolism in rats" @default.
- W2377027436 hasPublicationYear "2005" @default.
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