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- W2377029019 abstract "Osteoporosis( OP) is a systemic bone disease featured with lowbone mass density,bone fragility due to bone microstructural damage and prone to fracture. Trace elements in human and animal bones is necessary for growth and development,and play an important role in bone metabolism and turnover. Bone metabolism is regulated by many factors through systemic or local way,and is effected by minerals and elements acting on bone cells directly or indirectly. For example,fluorine concentrate at the site of newformed bone prmoting mesh structure and increaing bone mass; aluminum broken bone matrix by destroying the function of osteoblasts; magnesium promote bone turnover by stimulating osteoclast function; zinc act on the thyroid to regulate the secretion of calcium,affect bone turnover;,and promote the growth and differentiaion of osteogenesis conductine to bone calcification; copper inhibit osteoblasts and osteoclasts function leading to lowbone turnover; iodine involved in the composition of thyroid hormone leading to lowbone turnover. In addition,there are trace elements playing special role in human metabolism,such as copper, manganese,zinc and other activities involved in the composition and function of some enzymes,they regulate these enzymes to effect bone metabolism; selenium can maintain normal bone metabolism by selenoproteins antioxidative; Manganese is involved in activation of chondroitin sulfate synthetase system,and can stimulate the differentiation of osteoblasts. This paper riviews the research of zinc,selenium,manganese and strontium in osteoporosis,and provides theoreitc evidence for the prevention and treatment of osteoporosis using trace elements." @default.
- W2377029019 created "2016-06-24" @default.
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- W2377029019 date "2014-01-01" @default.
- W2377029019 modified "2023-09-28" @default.
- W2377029019 title "Research progress of Trace elements and Osteoporosis" @default.
- W2377029019 hasPublicationYear "2014" @default.
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