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- W2377029768 abstract "[Objective] To detect the expression of apoptotic mediators in glomeruli in adri-amycin-induced nephropathy in rats and the effect of enalapril on it. [ Methods ] 72 male SD rats aged 8 - 10 weeks were randomly divided into three groups: intervention group (IG), model group (MG) and control group (CG) . Each group had 24 rats. Rats in IG and MG were given adriamycin (doxorubicin) 2 mg/kg intravenously on the 1st and the 21st day respectively. At the same time, an equal volume of normal saline was given to the rats in CG by the same method. After the second injection, rats in IG received enalapril(50 mg/L) in their drinking water. 4 rats in each group were killed every 8 weeks from the 4lh week after the second injection. Apoptotic cells in kidney samples were detected by TUNEL method and electron microscopy. The expression of Fas antigen (CD95), Bcl-2 protein and AT2R in kidney samples were detected by immunohistochemical staining respectively. Gray values of positive staining in glomeruli were obtained by computer image analyzer and quantified as positive unit (PU). [Results] In IG and MG, glomerulosclerosis developed and the number of apoptotic cells in glomeruli increased after the 20th week. But glomerulosclerosis in IG was not so severer com- pared with that in MG at the 20th week. Glomerular cell apoptotic indexes (GAI) in IG at the 20th and 28th week were less than those in MG. The Fas antigen PUs in glomeruli were significantly increased and the Bcl-2 protein PUs in glomeruli were significantly decreased in IG and MG compared with CG at the 20th and 28th week. The Bcl-2 protein PUs in IG was significantly higher than that in MG at the 28th week. Expression of AT2R could not be detected in glomeruli. The PUs of Fas antigen and Bcl-2 protein in glomeruli in IG and MG were significantly correlated to glomerular sclerotic index (GSI) and GAI respectively. [Conclusion] In the process of gromerulosclerosis in adriamycin-induced nephropa-thy, glomerular cell apoptosis may be induced by the increased expression of Fas antigen and the decreased expression of Bcl-2 protein. Enalapril intervention can partially reverse the reduction of Bcl-2 expression in glomeruli, which may contribute to reduce apoptosis during glomerulosclerosis in IG." @default.
- W2377029768 created "2016-06-24" @default.
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- W2377029768 date "2003-01-01" @default.
- W2377029768 modified "2023-09-26" @default.
- W2377029768 title "The Expression of Apoptotic Mediators in Glomeruli in Adriamycin-induced Nephropathy in Rats and the Effect of ACEI" @default.
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