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- W2377037192 abstract "Objective:To investigate the protective effects of atorvastatin on endothelial progenitor cells(EPCs) undergoing ischemia-reperfusion injury and the possible mechanisms.Methods:Mononuclear cells from the bone marrow of SD rats were isolated by density gradient centrifugation,purified by selective plating technique and identified by indirect immunofluorescence assay.EPCs were divided randomly into five groups: control group(Group C),ischemia-reperfusion group(Group IR),Atorvastatin group(Group A),ischemia-reperfusion/atorvastatin group(Group IR/A) and atorvastatin/ischemia-reperfusion group(Group A/IR).The proliferation of EPCs was detected by MTT assay.The secretions of LDH,NO and TNOS in the cell-culture medium were measured.Results:The number of EPCs and the secretions of NO and TNOS decreased,while the secretion of LDH increased significantly in the ischemia-reperfusion model compared with group C(P0.05).However,the number of EPCs and the secretions of NO and TNOS increased,the secretion of LDH decreased after the pretreatment of atorvastatin compared with group IR(P0.05).Conclusion:Atorvastatin promotes proliferation and secretion of NO in the endothelial progenitor cells,which may be related to its effect on the secretion of TNOS." @default.
- W2377037192 created "2016-06-24" @default.
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- W2377037192 date "2013-01-01" @default.
- W2377037192 modified "2023-09-23" @default.
- W2377037192 title "Protective effects of atorvastatin on endothelial progenitor cells against ischemia-reperfusion injury" @default.
- W2377037192 hasPublicationYear "2013" @default.
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