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- W2377046098 abstract "OBJECTIVE To compare bioavailability of the two preparations of cetirizine dihydrochloride.METHODS The plasma concentrations of cetirizine in 20 healthy male volunteers after oral administration of cetirizine dihydrochloride capsules and cetirizine dihydrochloride tablets were determined by the improved HPLC, using hydroxyzine dihydrochloride as the internal standard. The plasma concentration-time curves and major pharmacokinetic parameters of tests and reference preparation were obtained.RESULTS The major pharmacokinetic parameters of tests and reference preparation were as follows:C_ max were (905.7±185.9) and (777.1±105.8)ng/mL, T_ max were (0.79±0.26) and (0.90±0.45)h, t_ 1/2 were (7.59±1.29) and (7.73±1.46)h, AUC_ 0→∞ were (6774.8± 1059.1 ) and (6603.2±1257.6) ng·h/mL, respectively. According to AUC_ 0→∞ , the relative bioavailability of cetirizine dihydrochloride was (104.0 ± 14.4) %.CONCLUSION Results by ANOVA analysis and two-side t-test shows that there is no obvious difference in availability between the two preparations (P0.05), and the two preparations are bioequivalent." @default.
- W2377046098 created "2016-06-24" @default.
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- W2377046098 date "2006-01-01" @default.
- W2377046098 modified "2023-09-25" @default.
- W2377046098 title "Comparision of bioavailability of two preparations of cetirizine dihydrochloride" @default.
- W2377046098 hasPublicationYear "2006" @default.
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