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- W2377052227 abstract "Aim: To investigate the therapeutic effects of human neural stem cells(NSCs) transplantion on rat traumatic brain injury. Methods: NSCs were derived from human fetal subventricular zone and labled with fluorescein Hoechest33258 before transplantation.A total of 54 rats were randomly divided into 3 groups: sham injury group(A),treatment control group(B),and NSCs transplantation group(C). After experimental traumatic brain injury,NSCs were injected into rat cortex of group C,and normal saline was given to rats in group B.The motor function scores of rats were assessed at 2 d and 7 d after transplantation,study and memory abilities were observed by Y maze test at 2 weeks and 4 weeks after transplantation. At different time points after transplantation the animals were sacrificed and their brains were examined by immunohistology using GFAP and NSE staining. Results: Significant differences were observed in motor function scores at 2 d after transplantation among 3 groups(P=0.00),and no difference was observed between group B and C(P=0.09).Significant differences were observed in motor function scores at 7 d after transplantation among 3 groups(P=0.00),and no difference was observed between group A and C(P=0.10). There were significant differences in study and memory abilities among 3 groups (P=0.00),and differences were observed between group B and C(P=0.00).Lebelling NSCs could be found in group C. Conclusion:Implanted human NSCs can survive, and migrate to injuried zone and differentiate in traumatic rat brain,and improve motor function scores and study and memory abilities." @default.
- W2377052227 created "2016-06-24" @default.
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- W2377052227 date "2006-01-01" @default.
- W2377052227 modified "2023-09-25" @default.
- W2377052227 title "Therapeutic effect of human neural stem cell transplantation on rat traumatic brain injury" @default.
- W2377052227 hasPublicationYear "2006" @default.
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