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- W2377054115 abstract "Objective To explore the protective effects of minocycline against apoptosis of hippocampal neurons and the relationships between doses.Methods Treated epileptic rats induced by pentylenetetrazol(PTZ) with different doses of minocycline using gavage method,the brain perfusion preparaed for paraffin sections and immunohistochemistry,the changes of apoptosis in rat hippocampus were observed by image analysis of HPIAS-1000 high-resolution color graphic analysis system pathology image analysis.Results Compared with PTZ group,apoptosis decreased in control group(P0.05);compared with PTZ group,apoptosis had no difference in MT1 group(P 0.05);compared with PTZ group,apoptosis decreased in MT2 group(P0.05);compared with PTZ group,apoptosis increased in MT3 group(P0.05).Comparison among the intervention group,compared with MT3 group and MT1 groups apoptosis decreased in MT2 apoptosis(P0.05).Conclusion Minocycline has neuroprotective effects in the appropriate concentration range." @default.
- W2377054115 created "2016-06-24" @default.
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- W2377054115 date "2011-01-01" @default.
- W2377054115 modified "2023-09-26" @default.
- W2377054115 title "Protection of Minocycline against apoptosis of hippocampal neurons of epileptic rats induced by Bentylenetetrazol(PTZ)" @default.
- W2377054115 hasPublicationYear "2011" @default.
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