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- W2377061451 abstract "Objective:To explore an analysis method for apparent receptor kinetics from synaptic response in motoneurons(MNs) in spinal cord slices in vitro.Methods:The intracellular recordings were performed in MNs of spinal cord slices isolated from neonatal rats(8-14 days old),and excitatory postsynaptic potentials(EPSPs) were evoked by ipsilateral ventrolateral funiculus(iVLF) electrical stimulation(iVLF-EPSP).Three types of iVLF-EPSPs with different kinetic process evoked by threshold stimulus intensity(T) were selected for analysis of the apparent receptor kinetics.The linearized formulas of receptor kinetics of association and dissociation kinetic curves were applied to estimate the apparent association rate constant(K1),dissociation rate constant(K2),equilibrium dissociation constant(KT) and maximum response(Vmax) by linear regression analysis of the rising phase and declining phase of iVLF-EPSPs.Results:Among 15 MNs with iVLF-EPSPs,parametric analysis of iVLF-EPSPs in 6 MNs indicated that amplitude and area under curve were both positively correlated with the intensity of stimulation(P0.01 and P 0.05).Linear regression analyses of separate 3 types of iVLF-EPSPs in rising phase and declining phase evoked by threshold stimulation led to values of correlation coefficient(r) of 0.9397-0.9621(all P 0.01) and-0.8836——0.9690(all P0.01) for linearization of association and dissociation kinetic curves,and the values of(0.364-2.330) T-1·ms-1,(0.055-0.189) ms-1,(0.025-0.284) T and(1.968-4.367) mV for K1,K2,KT and Vmax,respectively.Conclusion:Apparent receptor kinetics analysis may be applied to examination of the transmitter-receptor binding kinetics in synaptic response and tends to be a simple and feasible approach to estimate the receptor kinetics property in synaptic plasticity research." @default.
- W2377061451 created "2016-06-24" @default.
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- W2377061451 date "2013-01-01" @default.
- W2377061451 modified "2023-09-26" @default.
- W2377061451 title "Analysis of the apparent receptor kinetics from synaptic responses in spinal cord motoneurons in vitro" @default.
- W2377061451 hasPublicationYear "2013" @default.
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