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- W2377065022 abstract "Rhabdomyosarcoma is a malignant soft tissue neoplasm. Chemotherapy constitutes the chief supplementary method in the treatment of rhabdomyosarcoma. However, the appearance of multidrug resistance (MDR) is a major obstacle to successful chemotherapy. In the present study, a multidrug resistant cell line cell line RD/VCR, which showed a typical resistant phenotype to anti-cancer drugs, was induced in vitro by vincristine (VCR). Morphological changes were found in the ultra structure. The expression of mdrl and mrp gene, P-glycoprotein (P-gp) and multidrug resistance associated protein (MRP) were detected by RT-PCR and immunohistochemistry respectively. The mechanism of MDR in rhabdomyosarcoma might be associated with the expression of these genes and proteins." @default.
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- W2377065022 date "2004-01-01" @default.
- W2377065022 modified "2023-10-01" @default.
- W2377065022 title "Establishment of a multidrug resistant rhabdomyosarcoma cell line RD/VCR" @default.
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