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- W2377079254 abstract "Objective:To investigate the effect of aqueous extract of Polygala tenuifolia(APT) on myocardial contractility and atrial natriuretic peptide(ANP) secretion in beating rabbit atria.Method: The APT-induced changes in atrial dynamics,cAMP efflux and ANP secretion were determined in perfused beating rabbit atria.The changes of cAMP and ANP were measured by radioimmunoassay.Result: APT increased atrial stroke volume,pulse pressure and cAMP efflux in a concentration-dependent manner with inhibition of ANP secretion in beating rabbit atria.The APT-induced positive inotropic effect was significantly blocked by pretreatment with blockade of β and β1-adrenoceptors(AR)(P0.05) but not β2-AR.Furthermore,the APT-induced changes in myocardial contractility were attenuated by inhibition of L-type Ca2+channel and protein kinase A(PKA) activation with no changes in cAMP efflux.Conclusion: APT could increase atrial dynamics via β1-AR-cAMP-Ca2+signaling and decreases ANP secretion in beating rabbit atria." @default.
- W2377079254 created "2016-06-24" @default.
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- W2377079254 date "2013-01-01" @default.
- W2377079254 modified "2023-09-23" @default.
- W2377079254 title "Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria" @default.
- W2377079254 hasPublicationYear "2013" @default.
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