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- W2377085667 abstract "OBJECTIVE:To explore the effects of arsenic trioxide on radiosensitivity and the possible mechanism in lung cancer xenografts.METHODS:The tumor-bearing C57BL/6 mouse model was established by injecting Lewis lung cancer cells into right infra-axillary dermis.40 mice were randomized into 4 groups:control group(peritoneal injection 0.9%NS,0.2 ml);As_2O_3 group(peritoneal injection,2.0 mg/kg,0.2 ml As_2O_3);irradiation group(peritoneal injection 0.9% NS,0.2 ml + 6MeV Electron Beam,10 Gy);As_2O_3 + irradiation group(peritoneal injection,2.0 mg/kg,0.2 ml As_2O_3 + 6MeV Electron Beam,10 Gy).After experiments,mice were sacrificed,then the tumors were separated and weighed.Response to irradiation was evaluated by tumor-inhibiting rate.The expressions of VEGF and Ku70 mRNA were evaluated by RT—PCR. The protein levels of VEGF and Ku70 were measured by immunohistochemical staining.RESULTS:The Lewis lung cancer-bearing model was successfully established in mice.As_2O_3 + irradiation could significantly increase the tumor-inhibiting rate and downregulate the expression of VEGF and Ku70 of irradiated carcinoma xenografts,(Compared with As_2O_3 group or irradiation group,P0.05).CONCLUSION:Arsenic trioxide could sensitize lung cancer xenografts to ionizing irradiation. This effect was probably mediated by downregulating the expressions of VEGF and Ku70." @default.
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- W2377085667 date "2011-01-01" @default.
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- W2377085667 title "Radiosensitization effects of arsenic trioxide in lung cancer xenografts" @default.
- W2377085667 hasPublicationYear "2011" @default.
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