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- W2377089076 abstract "Objective To investigate whether COX-2-derived PGE2 regulates matrix metalloproteinase(MMP)-3 production in human periodontal ligament(PDL) cells stimulated with interleukin(IL)-1α.Methods Human PDL cells obtained from periodontally healthy subjects were stimulated with vehicle or IL-1α in the presence or absence of indomethacin(a COX-1/COX-2 inhibitor),NS-398(a specific COX-2 inhibitor),and PGE2.PGE2 levels were assayed by enzyme-linked immunosorbent assay(ELISA).MMP-3 levels and caseinolytic activities were evaluated by ELISA and casein zymography,respectively.Results IL-1α enhanced both MMP-3 and PGE2 production.Indomethacin and NS-398 enhanced IL-1α-induced MMP-3 production in PDL cells,to the same extent,although both the agents completely inhibited IL-1α-induced PGE2 production.Exogenous PGE2 reduced IL-1α-induced MMP-3 production in a dose-dependent manner.Conclusion COX-2-dependent PGE2 downregulates IL-1α-elicited MMP-3 production." @default.
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- W2377089076 date "2012-01-01" @default.
- W2377089076 modified "2023-09-23" @default.
- W2377089076 title "Effect of prostaglandin E_2 on matrix metalloproteinase-3 production in human periodontal ligament cells stimulated with interleukin-1α" @default.
- W2377089076 hasPublicationYear "2012" @default.
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