Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377091130> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2377091130 abstract "Objective To investigate and compare the effects of recombinant human interferon α1b, Yanhuning and Xiyanping on antagonizing respiratory syncytial virus(RSV) and regulating T lymphocyte subsets in RSV infected mice. Methods BALB/c mice were divided into eight groups randomly and the RSV infected-mouse model was established. Groups were given inhaled recombinant human interferon α1b of 12.5 μg and 25.0 μg, intraperitoneal injection of recombinant human interferon α1b(12.5 μg/kg), ribavirin(123.3 mg/kg), Xiyanping(61.65 mg/kg) and Yanhuning(61.65 mg/kg), respectively in five consecutive days. RSV infection positive and negative control groups were also set. The eyeball blood of mice was taken in the sixth day and the levels of CD3+CD4+, CD3+CD8+ in peripheral blood were tested by flow cytometry. The lung histopathology of sterile sectional lung tissue was observed by light microscopy and transmission electron microscope, and the fluorescence quantitative PCR was used to test the RSV load. Results The mouse model of RSV infection was successfully established. Significant inflammatory injury in RSVinfection positive mice's lungs was observed under light microscope and transmission electron microscopy. After treatments of recombinant human interferon α1b, Yanhuning or Xiyanping, the mice lung tissue showed recovery of inflammation with different degrees and RSV load significantly decreased. Wherein, the group of inhaled recombinant human interferon α1b 25.0 μg had the lightest degree of damage and the lowest RSV load. Intraperitoneal injected Xiyanping and Yanhuning groups were less effective. There were statistically significant differences between each group(P 0.05). Compared to RSV-infection positive group, the CD3+CD8+ level in the peripheral blood was increased, while CD3+ CD4+ and CD3+CD4+/CD3+CD8+ levels were decreased in recombinant human interferon α1b, Yanhuning and Xiyanping treated group with significant difference(P 0.05). Wherein, the group with inhaled 25.0 μg recombinant human interferon α1b showed regulations of T lymphocyte subsets significantly, followed by Xiyanping and Yanhuning intraperitoneal injected groups with significant differences(P 0.05). There was no significant difference between Xi yanping and Yanhuning group(P 0.05). Conclusions Recombinant human interferon α1b, Xiyanping and Yanhuning all played a role in anti-RSV effects and T lymphocyte subsets regulation. Among these treatments, the group with inhaled recombinant human interferon α1b 25.0 μg had the most significant effect." @default.
- W2377091130 created "2016-06-24" @default.
- W2377091130 creator A5064114625 @default.
- W2377091130 date "2013-01-01" @default.
- W2377091130 modified "2023-09-24" @default.
- W2377091130 title "Comparison of the effects of recombinant human interferon α1b, Yanhuning and Xiyanping against respiratory syncytial virus infection" @default.
- W2377091130 hasPublicationYear "2013" @default.
- W2377091130 type Work @default.
- W2377091130 sameAs 2377091130 @default.
- W2377091130 citedByCount "0" @default.
- W2377091130 crossrefType "journal-article" @default.
- W2377091130 hasAuthorship W2377091130A5064114625 @default.
- W2377091130 hasConcept C104317684 @default.
- W2377091130 hasConcept C126322002 @default.
- W2377091130 hasConcept C142462285 @default.
- W2377091130 hasConcept C142724271 @default.
- W2377091130 hasConcept C159047783 @default.
- W2377091130 hasConcept C203014093 @default.
- W2377091130 hasConcept C2522874641 @default.
- W2377091130 hasConcept C2776178377 @default.
- W2377091130 hasConcept C2777714996 @default.
- W2377091130 hasConcept C2780159080 @default.
- W2377091130 hasConcept C40767141 @default.
- W2377091130 hasConcept C534529494 @default.
- W2377091130 hasConcept C544855455 @default.
- W2377091130 hasConcept C55493867 @default.
- W2377091130 hasConcept C71924100 @default.
- W2377091130 hasConcept C86803240 @default.
- W2377091130 hasConceptScore W2377091130C104317684 @default.
- W2377091130 hasConceptScore W2377091130C126322002 @default.
- W2377091130 hasConceptScore W2377091130C142462285 @default.
- W2377091130 hasConceptScore W2377091130C142724271 @default.
- W2377091130 hasConceptScore W2377091130C159047783 @default.
- W2377091130 hasConceptScore W2377091130C203014093 @default.
- W2377091130 hasConceptScore W2377091130C2522874641 @default.
- W2377091130 hasConceptScore W2377091130C2776178377 @default.
- W2377091130 hasConceptScore W2377091130C2777714996 @default.
- W2377091130 hasConceptScore W2377091130C2780159080 @default.
- W2377091130 hasConceptScore W2377091130C40767141 @default.
- W2377091130 hasConceptScore W2377091130C534529494 @default.
- W2377091130 hasConceptScore W2377091130C544855455 @default.
- W2377091130 hasConceptScore W2377091130C55493867 @default.
- W2377091130 hasConceptScore W2377091130C71924100 @default.
- W2377091130 hasConceptScore W2377091130C86803240 @default.
- W2377091130 hasLocation W23770911301 @default.
- W2377091130 hasOpenAccess W2377091130 @default.
- W2377091130 hasPrimaryLocation W23770911301 @default.
- W2377091130 hasRelatedWork W1964528364 @default.
- W2377091130 hasRelatedWork W2010288671 @default.
- W2377091130 hasRelatedWork W2026959690 @default.
- W2377091130 hasRelatedWork W2027313673 @default.
- W2377091130 hasRelatedWork W2042576852 @default.
- W2377091130 hasRelatedWork W2132495865 @default.
- W2377091130 hasRelatedWork W2350172852 @default.
- W2377091130 hasRelatedWork W2366757107 @default.
- W2377091130 hasRelatedWork W2370337340 @default.
- W2377091130 hasRelatedWork W2371472238 @default.
- W2377091130 hasRelatedWork W2372502437 @default.
- W2377091130 hasRelatedWork W2374304600 @default.
- W2377091130 hasRelatedWork W2379721042 @default.
- W2377091130 hasRelatedWork W2387684103 @default.
- W2377091130 hasRelatedWork W2389783121 @default.
- W2377091130 hasRelatedWork W2393812155 @default.
- W2377091130 hasRelatedWork W2415219319 @default.
- W2377091130 hasRelatedWork W2417874692 @default.
- W2377091130 hasRelatedWork W2418680643 @default.
- W2377091130 hasRelatedWork W3098588025 @default.
- W2377091130 isParatext "false" @default.
- W2377091130 isRetracted "false" @default.
- W2377091130 magId "2377091130" @default.
- W2377091130 workType "article" @default.