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- W2377093708 abstract "Objective:To study the significance of endoplasmic reticulum stress in hepatocytes apoptosis.Methods:The BALB/c mouse primary hepatocytes were isolated by two-step in situ liver perfusion,and then induced apoptosis with 4 μmol/L thapsigargin.siRNA against caspase-12 were synthesized chemically,then transfected into mouse primary hepatocytes by liposomes.Efficacy of caspase-12-siRNA inhibition was analyzed with RT-PCR and Western blot;viability of hepatocyte following apoptosis was evaluated with MTT.Results:The inhibition of caspase-12 mRNA and procaspase-12 expression were 86.22% and 50.04% respectively with 200 nmol/L siRNA(P0.01).Contrasted with apoptotic hepatocytes,the cell activity analyzed with MTT increased by 51.65%(P0.05).Conclusions:The mouse primary hepatocyte apoptosis can be reduced when endoplasmic reticulum stress-induced caspase-12 is inhibited.Endoplasmic reticulum stress plays an important role in hepatocyte apoptosis." @default.
- W2377093708 created "2016-06-24" @default.
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- W2377093708 date "2010-01-01" @default.
- W2377093708 modified "2023-09-22" @default.
- W2377093708 title "Significance of endoplasmic reticulum stress in hepatocytes apoptosis" @default.
- W2377093708 hasPublicationYear "2010" @default.
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