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- W2377095345 abstract "Objective: To observe the effect on the expression of calcitonin gene-related peptide (CGRP) after different time-delayed repair of sciatic nerve defect in rats. Methods: After the predegeneration time of 0d, 3d, 7d, 14d and 21d (n=6) respectively, the right (ipsilateral) sciatic nerve defects of rats were bridged with contralateral fresh nerves. The animals were sacrificed after a survival time of 6 weeks and the expression of CGRP in spinal cord and dorsal root ganglion (DRG) was detected by immunohistochemical method. Results: The expression of CGRP in ipsilateral DRG and the CGRP immuno-positive area in ipsilateral spinal dorsal horn of all groups significantly increased than that in contralateral DRG and spinal dorsal horn (P0.05). The expression of CGRP in ipsilateral DRG as well as the CGRP immuno-positive area in ipsilateral spinal dorsal horn of 21d group was obviously higher than that of 0d group (P0.05). Compared with contralateral spinal cord, the expression of CGRP in ipsilateral spinal dorsal horn of 0d, 3d and 21d groups and in ipsilateral spinal anterior horn of 3d group significantly increased (P0.05). Meanwhile, the increase of CGRP expression in ipsilateral spinal dorsal horn of 3d and 21d groups, as well as in ipsilateral spinal anterior horn of 3d group had statistic significance (P0.05). Conclusions: The treatment of predegeneration well effect on the expression of CGRP and regeneration after nerve injury." @default.
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- W2377095345 date "2005-01-01" @default.
- W2377095345 modified "2023-09-23" @default.
- W2377095345 title "Effect on the expression of CGRP after different time-delayed repair sciatic nerve defect in rats" @default.
- W2377095345 hasPublicationYear "2005" @default.
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