Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377097679> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2377097679 endingPage "33" @default.
- W2377097679 startingPage "928" @default.
- W2377097679 abstract "To prevent acute graft-versus-host disease (aGVHD), glucosidorum tripterygii tororum (GTT) was used in the murine model. The lethally irradiated C57BL/6 recipients were injected with bone marrow and lymphocyte grafts from BALB/c donors and were treated intraperitoneally with GTT, cyclosporine A (CsA), or methotrexate (MTX). T lymphocytes, adhesion molecules and cytokines were detected by immunohistochemical method, flow cytometry, ELISA and RT-PCR, respectively. The results showed that all the control recipient mice (21/21) died of aGVHD within 30 days, but many recipient mice treated with GTT (19/21), CsA + MTX (13/21) and GTT + CsA (17/21) survived beyond 30 days without obvious signs of aGVHD. The numbers of CD3(+), CD4(+), CD8(+), CD11a(+), CD18(+) lymphocytes in skin and lung decreased markedly by GTT, GTT + CsA and CsA + MTX treatments. The numbers of CD3(+), CD4(+), CD8(+), CD4(+)CD11a(+), CD4(+)CD18(+), CD8(+)CD11a(+), CD8(+)CD18(+) lymphocytes in spleen decreased markedly by GTT, GTT + CsA and CsA + MTX treatments. and the changes of CD3(+), CD4(+), CD8(+) cells in small intestine were not remarkable (P > 0.05) by above mentioned GTT, GTT + CsA and CsA + MTX treatments. The serum concentrations and mRNA expressions of IL-2 and TNFalpha in spleens decreased significantly (P < 0.05); the concentration of IL-10 increased significantly (P < 0.05), the change of IL-4 was not remarkable (P > 0.05) by GTT treatment. It is concluded that the GTT may retain the graft-versus-leukemia (GVL) effect of transplant without aGVHD. The role of GTT in prevention of murine aGVHD is mediated by reduction of T lymphocytes and their subgroups, expression of adhesion molecule, and regulation of cytokine secretion." @default.
- W2377097679 created "2016-06-24" @default.
- W2377097679 creator A5046597133 @default.
- W2377097679 creator A5057202795 @default.
- W2377097679 creator A5060804329 @default.
- W2377097679 creator A5075320999 @default.
- W2377097679 creator A5078164975 @default.
- W2377097679 creator A5078566134 @default.
- W2377097679 date "2006-10-01" @default.
- W2377097679 modified "2023-09-24" @default.
- W2377097679 title "[Effect of glucosidorum tripterygii tororum on acute graft-versus-host disease in mice]." @default.
- W2377097679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17096891" @default.
- W2377097679 hasPublicationYear "2006" @default.
- W2377097679 type Work @default.
- W2377097679 sameAs 2377097679 @default.
- W2377097679 citedByCount "0" @default.
- W2377097679 crossrefType "journal-article" @default.
- W2377097679 hasAuthorship W2377097679A5046597133 @default.
- W2377097679 hasAuthorship W2377097679A5057202795 @default.
- W2377097679 hasAuthorship W2377097679A5060804329 @default.
- W2377097679 hasAuthorship W2377097679A5075320999 @default.
- W2377097679 hasAuthorship W2377097679A5078164975 @default.
- W2377097679 hasAuthorship W2377097679A5078566134 @default.
- W2377097679 hasConcept C126322002 @default.
- W2377097679 hasConcept C134018914 @default.
- W2377097679 hasConcept C147483822 @default.
- W2377097679 hasConcept C167672396 @default.
- W2377097679 hasConcept C203014093 @default.
- W2377097679 hasConcept C2777761686 @default.
- W2377097679 hasConcept C2780931953 @default.
- W2377097679 hasConcept C2781059491 @default.
- W2377097679 hasConcept C71924100 @default.
- W2377097679 hasConceptScore W2377097679C126322002 @default.
- W2377097679 hasConceptScore W2377097679C134018914 @default.
- W2377097679 hasConceptScore W2377097679C147483822 @default.
- W2377097679 hasConceptScore W2377097679C167672396 @default.
- W2377097679 hasConceptScore W2377097679C203014093 @default.
- W2377097679 hasConceptScore W2377097679C2777761686 @default.
- W2377097679 hasConceptScore W2377097679C2780931953 @default.
- W2377097679 hasConceptScore W2377097679C2781059491 @default.
- W2377097679 hasConceptScore W2377097679C71924100 @default.
- W2377097679 hasIssue "5" @default.
- W2377097679 hasLocation W23770976791 @default.
- W2377097679 hasOpenAccess W2377097679 @default.
- W2377097679 hasPrimaryLocation W23770976791 @default.
- W2377097679 hasRelatedWork W101569894 @default.
- W2377097679 hasRelatedWork W2034458260 @default.
- W2377097679 hasRelatedWork W2057514629 @default.
- W2377097679 hasRelatedWork W2061810621 @default.
- W2377097679 hasRelatedWork W2063703098 @default.
- W2377097679 hasRelatedWork W2069293597 @default.
- W2377097679 hasRelatedWork W2324347192 @default.
- W2377097679 hasRelatedWork W2364287555 @default.
- W2377097679 hasRelatedWork W2377252687 @default.
- W2377097679 hasRelatedWork W2395886739 @default.
- W2377097679 hasRelatedWork W2406316869 @default.
- W2377097679 hasRelatedWork W2410152596 @default.
- W2377097679 hasRelatedWork W2419603797 @default.
- W2377097679 hasRelatedWork W253744647 @default.
- W2377097679 hasRelatedWork W2621878426 @default.
- W2377097679 hasRelatedWork W2729668897 @default.
- W2377097679 hasRelatedWork W2977334137 @default.
- W2377097679 hasRelatedWork W3093744457 @default.
- W2377097679 hasRelatedWork W3145684529 @default.
- W2377097679 hasRelatedWork W2129201593 @default.
- W2377097679 hasVolume "14" @default.
- W2377097679 isParatext "false" @default.
- W2377097679 isRetracted "false" @default.
- W2377097679 magId "2377097679" @default.
- W2377097679 workType "article" @default.