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- W2377098192 abstract "Objective: To investigate the effect of high-fat medium on the activition of hepatic stellate cells. Methods: HSC-T6 cell line was cultured, and treated with high-fat medium which containing free fatty acid, activated with LPS. The degree of activation was analyzed by detecting α-SMA expression. The expression of collagen-I and TIMP-1 was analyzed by Q-PCR, and the activation of transcription factor which related to LPS pathway was analyzed by Q-PCR assay. Results: High-fat medium was able to inhibit the activation of HSC-T6 cells which induced by LPS, reduced the expression of collagen level in the HSC-T6 cells. Q-PCR analysis showed that the high-fat medium inhibited the expression of MCP-1 and IL-6 which were the target genes of NF-κB in activated HSCs. Conclusion: In vitro culture experiments, high-fat medium can inhibit the activation of HSC-T6 cells which induced by LPS." @default.
- W2377098192 created "2016-06-24" @default.
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- W2377098192 date "2014-01-01" @default.
- W2377098192 modified "2023-09-26" @default.
- W2377098192 title "The Fat Culture Inhabited LPS-Induced Activation of HSCs-T6 Cells" @default.
- W2377098192 hasPublicationYear "2014" @default.
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