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- W2377113662 abstract "Objective To investigate the efficacy of BIS-guided sedation with midazolam administered by target controlled infusion (TCI) in surgical intensive care unit (SICU) patients. Methods Thirty SICU patients aged 25-75 yrs weighing 55-85 kg on mechanical ventilation for at least 12h were randomly assigned to one of 3 groups ( n = 10 each): group A received a bolus of midazolam 0.04 mg·kg-1 followed by continuousⅣinfusion at 0.06 mg·kg-1·h-1 ; group B and C received TCI of midazolam (initial target plasma concentration 60 ng·ml-1). In group A and B the depth of sedation was maintained at Ramsay score of 4 by adjusting the infusion rate or target plasma concentration while in group C the depth of sedation was maintained at BIS score of 70. In group B and C blood samples were taken from artery at different target plasma midazolam levels for determination of plasma midazolam concentration to evaluate the performance of TCI of midazolam. Results The median performance error (MDPE) of midazolam TCI system was 12.5% and the median absolute performance error (MDAPE) was 22.5% . Both of them were clinically acceptable. The correlation coefficient between the measured plasma midazolam concentration and Ramsay sedation score was 0.67. In group C while the patients were being appropriately sedated the percentage of Ramsay score of 4 was 53.9% which was significantly higher than in group A (28.5 % ) and B (40% ) ( P 0.01) . Conclusion The efficacy of midazolam TCI system is clinically acceptable. The BIS guided sedation with midazolam administered by TCI is more suitable for SICU patients." @default.
- W2377113662 created "2016-06-24" @default.
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- W2377113662 date "2006-01-01" @default.
- W2377113662 modified "2023-09-26" @default.
- W2377113662 title "BIS-guided sedation with midazolam administered by TCI in SICU patients" @default.
- W2377113662 hasPublicationYear "2006" @default.
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