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- W2377127877 abstract "Objective To compare in vitro antitumor effects of controlled biodegradable drug release system and simplex anti-tumor drug in the patients with glioma.Methods After selecting optimal dose of drug by MTT method,polylactide(PLA) was mixed with BCNU,adriamycin and taxol,respectively,to make them into controlled release systems by chemical and electric spindle technics,and their controlled release rates were measured by high-performance liquid chromatography(HPLC),from which the best system was selected based on the release rate.After L929 cells were cultured in empty vector lixivium in vitro,OD value was measured,relative growth rate(RGR) calculated,and toxicity of the empty vector evaluated according to 6-grade scoring criteria.Grades 0-1 are avirulent.Cell inhibition rate(IR) was calculated after C6 glioma cells were cultured in the controlled drug release system for testifying tumor-killing effect of the controlled drug release system.Results Efficacy of controlled release of BCNU-PLA and adriamycin-PLA release systems is steady,but that of taxol-PLA controlled release system is not steady with a sudden release.Empty vector toxicity was at grades 0-1.Inhibition rate of cell growth by controlled BCNU-PLA release system was 12.3%.Conclusion Vector material is not toxic.The controlled BCNU-PLA release system can kill glioma cells in vitro effectively and consistently,and the efficacy can be validated through further animal experiments." @default.
- W2377127877 created "2016-06-24" @default.
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- W2377127877 date "2006-01-01" @default.
- W2377127877 modified "2023-09-25" @default.
- W2377127877 title "In vitro study of controlled biodegradable high molecular superfine fiber PLA release system for glioma" @default.
- W2377127877 hasPublicationYear "2006" @default.
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