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- W2377130685 abstract "OBJECTIVE: To discuss the protective effect of captopril on the nicotine-induced impairment of endothelium-dependent relaxation(EDR) in rat mesenteric arteries and explore the possible mechanisms underlying the observed protective effects of captopril.METHODS: A total of 30 rats were randomly divided into 3 groups: normal control group,nicotine group(2 mg·kg-1),captopril group(nicotine 2 mg·kg-1+captopril 3 mg·kg-1).After treatment for 4 weeks,vasodilatation rate of mesenteric arteries,the content of NO and NOS,and the SOD activities in serum were measured.RESULTS: Nicotine significantly decreased the vasodilatation rate of mesenteric arteries and decreased the content of NO and NOS,SOD activities in serum(P0.01 or P0.05).However,captopril significantly increased the vasodilatation rate and inhibited the nicotine-induced decreases of the content of NO and the activities of NOS and SOD(P0.01).CONCLUSION: Captopril has remarkable protection on nicotine-induced endothelial dysfunction possibly related to its antioxidation,promoting synthesis of endothelial cells and NO release." @default.
- W2377130685 created "2016-06-24" @default.
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- W2377130685 date "2008-01-01" @default.
- W2377130685 modified "2023-09-27" @default.
- W2377130685 title "Protective Effect of Captopril on Nicotine-induced Endothelial Dysfunction in Rats" @default.
- W2377130685 hasPublicationYear "2008" @default.
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