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- W2377132364 abstract "Objective:To investigate the molecular mechanism of signal regulation in the proximal nerve after resection of the sciatic nerve by using gene microarray combined with Signal-Flow analysis.Methods:The proximal nerve tissues of 0.5cm were collected after the sciatic nerves of SD rats were transected at 0h,0.5h,1h,3h,6h and 9h,respectively.The dynamic gene regulatory network was inferred from time-series measurements of microarray data followed by screen of differential gene and pathway analysis.The mRNA expression was also further confirmed by qRT-PCR.Results:A total of 2850 differential genes were identified.Both anti-apoptosis factors and tight junction factors were the key elements in the gene regulatory network.Birc2,Birc3 and Tnfrsf1a were upregulated at the early stage,and inhibited the expression of apoptosis-related genes,whereas tight junction protein,cldn14,promoted the binding with other family members.Conclusion:Both anti-apoptosis factors and tight junction factors might be the early regulatory molecules involved in the nerve tissue regeneration,suggesting an association with the regulation of intrinsic growth capacity after nerve tissue injury." @default.
- W2377132364 created "2016-06-24" @default.
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- W2377132364 date "2010-01-01" @default.
- W2377132364 modified "2023-09-26" @default.
- W2377132364 title "Analysis of molecular regulation in nerve tissues at early stages following sciatic nerve transection" @default.
- W2377132364 hasPublicationYear "2010" @default.
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