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- W2377133724 abstract "Objective To examine the association between serum resistin levels and the severity of coronary artery lesions and cardiovascular risk factors in postmenopausal women.Methods The study population consisted of 117 postmenopausal women who underwent diagnostic coronary angiography for evaluation for suspected myocardial ischemia.Fasting serum resistin,insulin,blood glucose(BG),high-sensitive C-reactive protein(hs-CRP),fibrinogen(Fib)and lipid profile,including total cholesterol(TC),triglycerides(TG),HDL-cholesterol(HDL-C),LDL-cholesterol(LDL-C),apolipoprotein A1(Apo A1),apolipoprotein B(Apo B)and lipoprotein(a)(Lp(a))were measured in all the patients.Patients were divided into four groups according to the score of their coronary artery lesions:group Ⅰ included patients with coronary artery lesion score 0(no evidence of CAD),while group Ⅱ with score 1(mild lesion),group Ⅲ with score 2(moderate lesion),and group Ⅳ with score 3(severe lesion).Only patients with moderate to severe coronary lesions were diagnosed as coronary artery disease(CAD).Results Among the 117 patients,74 were diagnosed as CAD patients.Patients with CAD had significantly higher levels of resistin compared with controls:[4(1-10)μg/L vs 2(0-4)μg/L,median(interquartile range),P=0.002].In multiple logistic regression analysis,resistin levels were associated with CAD independent of age,BMI,metabolic syndrome,history of hypertension(HTN),diabetes(DM),dyslipidemia,smoking,SBP,DBP,hs-CRP,lipids [TC,TG,HDL-C,Apo A1,Apo B,Lp(a)],Fib,BG and insulin(OR 1.131,95%CI 1.012-1.263,P=0.030).Resistin levels correlated positively with CAD lesion severity in postmenopausal women(r=0.231,P0.001).The correlation remained significant even after controlling for age,BMI,metabolic syndrome,HTN,DM,dyslipidemia,SBP,DBP,hs-CRP,BG,insulin,Fib and lipid measurements(r=0.246,P=0.023).Resistin levels correlated positively with age and hs-CRP levels(r=0.204 and r=0.166,P=0.001 and P=0.009,respectively).Conclusion Serum resistin level is a possible independent risk factor of CAD in postmenopausal women,and may reflect the severity of coronary atherosclerosis.Resistin levels correlate positively with hs-CRP levels,therefore resistin may play an important role in the development of CAD by inflammatory mechanism." @default.
- W2377133724 created "2016-06-24" @default.
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- W2377133724 date "2007-01-01" @default.
- W2377133724 modified "2023-09-26" @default.
- W2377133724 title "Association of serum resistin levels with the severity of coronary artery lesions in postmenopausal women" @default.
- W2377133724 hasPublicationYear "2007" @default.
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