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- W2377138169 abstract "AIM To research the bionics extraction technology of Zuojin Pill and its improvement and optimization.METHODS To extract Zuojin Pill with different extracting agents and optimize it through acid variety and the change of pH value.Using the method of HPLC to determine the extracting percentage of main alkaloid of Zuojin Pill and verify experiment of pharmacodynamics of analgesia model.RESULTS After using the extract method of bionics for optimization,within the same time,extracting percentage of simulated gastric fluid was the best(artificial gastric juice 60%ethanol extracting solution artificial intestinal juice water extracting solution),and that could increase twice or more than twice than other methods and had significant difference compared with water and 60%ethanol extracting solution group(P0.05,P0.01),at the same time,it could come to peak value quickly within the shortest time.The results of the verification demonstrated that,in the biomimetic extracting solution,the effect was the best by adopting hydrochloric acid to set the value of pH.The results of the analgesia indicated that,artificial gastric juice group compared with the regular group,the increase rate of pain threshold existed significant difference(P0.05).CONCLUSION It is stable and feasible that using bionics extracting solution as extraction process.It can be used as Zuojin Pill extraction process and settle the base for dosage form alteration in the future." @default.
- W2377138169 created "2016-06-24" @default.
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- W2377138169 date "2011-01-01" @default.
- W2377138169 modified "2023-09-23" @default.
- W2377138169 title "The bionics extraction technology of Zuojin Pill" @default.
- W2377138169 hasPublicationYear "2011" @default.
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