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- W2377146164 abstract "Objective:To explore the relationship between single nucleotide polymorphism of human leukocyte antigen-G(HLA-G) gene upstream regulation region-725 and pathogenesis of severe preeclampsia by case-control study.Methods:Genomic DNA was extracted from peripheral whole blood of 40 cases in late pregnancy with preeclampsia,41 normal full-term pregnant women,5' upstream regulation region of HLA-G gene was amplified by specific primer and polymerase chain reaction,then DNA sequencing was carried out,genotype of-725 situs and frequency of allele were analyzed by chi-square test.Results:The frequencies of GG,GC and CC genotypes were 0%,7.5% and 92.5% in severe preeclampsia group,0%,7.3% and 92.7% in control group,respectively,there was no significant difference(P0.05).The frequencies of G and C alleles were 3.8% and 96.2% in severe preeclampsia group,3.7% and 96.3% in control group,respectively,there was no significant difference(P0.05).Conclusion:The single nucleotide polymorphism of HLA-G gene upstream regulation region-725 seems to be disconnected with pathogenesis of severe preeclampsia in Han population in Henan directly." @default.
- W2377146164 created "2016-06-24" @default.
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- W2377146164 date "2010-01-01" @default.
- W2377146164 modified "2023-09-25" @default.
- W2377146164 title "Relationship between single nucleotide polymorphism of HLA-G gene upstream regulation region-725 and susceptibility of severe preeclampsia" @default.
- W2377146164 hasPublicationYear "2010" @default.
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