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- W2377148949 abstract "Objective To screen the chemical components, extract, and injection, which have the inhibitory effect on cytochrome P4502D6 (CYP2D6) in liver microsomes of rats, from 17 kinds of Chinese materia medica (CMM) and develop a technical method for screening CMM possessed inhibitory effect on CYP2D6 in liver microsomes of rats by high throughout. MethodsThe liver microsomes of rats were incubated with 17 kinds of CMM at the presence of Dextromethorphan (DM). DM Metabolic rate (DX/DM, DX: Dextrophan, metabolites of DM) in liver microsomal reconstituted system was measured by HPLC and used as probe to determine the activity of CYP2D6. The inhibition of CMM on rat CYP2D6 was identified by decreasing the metabolic rate. ResultsQuercetin, baicalin, extract of Flos Magnoliae Officinalis, Qingkailing Injection, and Tetramethylpytazine Hydrochloride Injection inhibited the DM metabolic rate (P0.01). ConclusionFive kinds of CMM have been obtained, they are quercetin, baicalin, extract of Flos Magnoliae Officinalis, Qingkailing Injection, and Tetramethylpytazine Hydrochloride Injection, which can inhibit the activity of CYP2D6 in liver microsomes of rats. The method mentioned above can be used as a useful technique to high throughout screening of CMM possessed the inhibitory effect on CYP2D6." @default.
- W2377148949 created "2016-06-24" @default.
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- W2377148949 date "2007-01-01" @default.
- W2377148949 modified "2023-09-25" @default.
- W2377148949 title "Screening of Chinese materia medica possessed inhibitory effect on cytochrome P4502D6 in liver microsomes of rats" @default.
- W2377148949 hasPublicationYear "2007" @default.
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