Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377152856> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2377152856 abstract "Objective: To investigate the change of orexin and leptin system in hypothalamus and adipose tissue of insulin-resistant (IR) rats and analyze the regulatory factors. Methods: IR rat model was induced by fat-rich diet and approved by glucose clamp technique. RT-PCR was used to detect the expression of orexin/leptin and the receptor (OX1R, OX2R, LR) mRNAs while biochemical colorimetry was used for serum FFA detection and radioimmune assay for serum TNF-α. Results: In the hypothalamus of the IR rat model, the expression of prepro-orexin decreased by 80%. OX1R, OX2R increased by 3.4 folds and 3.2 folds respectively. Leptin mRNA increased by approximately 8 folds and LR reduced by 78%. Both serum FFA and TNF-α evidently increased and glucose infusion rate (GIR60-120) during glucose clamp was markedly lower than that in control group. Conclusions: Fat-rich diet can induce insulin resistance in rats and disturb the balance of orexin/leptin system. The interaction between orexin and leptin maintains the stability of energy metabolism in the body. FFA and TNF-α may also play a part in the regulation of orexin/leptin system." @default.
- W2377152856 created "2016-06-24" @default.
- W2377152856 creator A5076573406 @default.
- W2377152856 date "2004-01-01" @default.
- W2377152856 modified "2023-09-25" @default.
- W2377152856 title "Study of orexin/leptin system change and influencing factors in insulin-resistant rats" @default.
- W2377152856 hasPublicationYear "2004" @default.
- W2377152856 type Work @default.
- W2377152856 sameAs 2377152856 @default.
- W2377152856 citedByCount "0" @default.
- W2377152856 crossrefType "journal-article" @default.
- W2377152856 hasAuthorship W2377152856A5076573406 @default.
- W2377152856 hasConcept C118303440 @default.
- W2377152856 hasConcept C126322002 @default.
- W2377152856 hasConcept C134018914 @default.
- W2377152856 hasConcept C14372207 @default.
- W2377152856 hasConcept C170493617 @default.
- W2377152856 hasConcept C171089720 @default.
- W2377152856 hasConcept C185592680 @default.
- W2377152856 hasConcept C2776119998 @default.
- W2377152856 hasConcept C2777003273 @default.
- W2377152856 hasConcept C2777391703 @default.
- W2377152856 hasConcept C2779306644 @default.
- W2377152856 hasConcept C2779680196 @default.
- W2377152856 hasConcept C2780613262 @default.
- W2377152856 hasConcept C511355011 @default.
- W2377152856 hasConcept C71924100 @default.
- W2377152856 hasConcept C86803240 @default.
- W2377152856 hasConceptScore W2377152856C118303440 @default.
- W2377152856 hasConceptScore W2377152856C126322002 @default.
- W2377152856 hasConceptScore W2377152856C134018914 @default.
- W2377152856 hasConceptScore W2377152856C14372207 @default.
- W2377152856 hasConceptScore W2377152856C170493617 @default.
- W2377152856 hasConceptScore W2377152856C171089720 @default.
- W2377152856 hasConceptScore W2377152856C185592680 @default.
- W2377152856 hasConceptScore W2377152856C2776119998 @default.
- W2377152856 hasConceptScore W2377152856C2777003273 @default.
- W2377152856 hasConceptScore W2377152856C2777391703 @default.
- W2377152856 hasConceptScore W2377152856C2779306644 @default.
- W2377152856 hasConceptScore W2377152856C2779680196 @default.
- W2377152856 hasConceptScore W2377152856C2780613262 @default.
- W2377152856 hasConceptScore W2377152856C511355011 @default.
- W2377152856 hasConceptScore W2377152856C71924100 @default.
- W2377152856 hasConceptScore W2377152856C86803240 @default.
- W2377152856 hasLocation W23771528561 @default.
- W2377152856 hasOpenAccess W2377152856 @default.
- W2377152856 hasPrimaryLocation W23771528561 @default.
- W2377152856 hasRelatedWork W1043529915 @default.
- W2377152856 hasRelatedWork W1975894876 @default.
- W2377152856 hasRelatedWork W1999648379 @default.
- W2377152856 hasRelatedWork W2018145560 @default.
- W2377152856 hasRelatedWork W2019077662 @default.
- W2377152856 hasRelatedWork W2023412981 @default.
- W2377152856 hasRelatedWork W2038463607 @default.
- W2377152856 hasRelatedWork W2075353539 @default.
- W2377152856 hasRelatedWork W2080139868 @default.
- W2377152856 hasRelatedWork W2087318538 @default.
- W2377152856 hasRelatedWork W2093704872 @default.
- W2377152856 hasRelatedWork W2111232488 @default.
- W2377152856 hasRelatedWork W2136012661 @default.
- W2377152856 hasRelatedWork W2148083005 @default.
- W2377152856 hasRelatedWork W2154555913 @default.
- W2377152856 hasRelatedWork W2363637663 @default.
- W2377152856 hasRelatedWork W2507855427 @default.
- W2377152856 hasRelatedWork W2547749232 @default.
- W2377152856 hasRelatedWork W2912687419 @default.
- W2377152856 hasRelatedWork W2183301255 @default.
- W2377152856 isParatext "false" @default.
- W2377152856 isRetracted "false" @default.
- W2377152856 magId "2377152856" @default.
- W2377152856 workType "article" @default.