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- W2377155287 abstract "Objective To investigate the role of E-cadherin and Its Hypermethylation of CpG Island in Promotor Region in CINs and Cervical Carcinoma.Methods From October 2006 to October 2009,in 40 cases with Cervical Carcinoma,52 cases with CINs and 18 cases with normal cervix,E-cadherin and Its Hypermethylation of CpG Island in Promotor Region were detected by using immunohistochemical Method and methylation specitic polymerase chain reaction(MSP)respectively.Results The result showed that the depressing trend in the expression of E-cadherin was obvious in series of cervical lesion and there were significant difference between each two group(P0.05),whereas that of its hypermethylation of CpG island in Promotor Region was inverse(P0.05).There was significantly correlated with clinic stages and histological type(P0.05).In 40 patients of cervical carcinoma,the expression of E-cadherin in group methylation was clearly lower than those of group non-methylation.Conclusion Inactivation of E-cadherin gene expression is an important factor in the uterine cervical carcinogenesis,which could be throught the mechanism of hypermethylation of CpG island in its Promotor Region." @default.
- W2377155287 created "2016-06-24" @default.
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- W2377155287 date "2010-01-01" @default.
- W2377155287 modified "2023-09-24" @default.
- W2377155287 title "Study of Expression of E-cadherin and Its Relation with Hypermethylation of CpG islandin Promotor Region in CINs and Cervical Carcinoma" @default.
- W2377155287 hasPublicationYear "2010" @default.
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