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- W2377173871 abstract "To explore protective effects of tea polyphenol(-)-epigallocatechin gallate(EGCG) against injury induced by hydroxyl radical in cultured hippocampal neurons.primarily cultured neurons were dissociated from 18 day old embryonic mouse hippocampus,after being cultured 4 days in vitro.EGCG was added into medium to pretreat these cells at different concentrations following treatment of H_(2)O_(2).and FeSO_(4),then went on to cultured for 24 hours.Morphological changes of these cells were observed,neuronal viability was measured by MTT assay,in addition.malondialdehyde(MDA) of production in cultured neurons and levels of LDH in this media were detected.Eventually these changes were compared among different groups.This study indicated that EGCG can attenuate production of MDA in hippocamal neurons,decrease released levels of LDH in cultured media,and attenuate injury caused by hydroxyl radical,furthermore EGCG had neuroprotective effects on hippocampal neuronal survival.These results demonstated that EGCG may act further as neuroprotive agent against central nervous system pathological damage in clinical therapy." @default.
- W2377173871 created "2016-06-24" @default.
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- W2377173871 date "2005-01-01" @default.
- W2377173871 modified "2023-09-23" @default.
- W2377173871 title "Effects of Tea Polyphenol(-)-Epigallocatechin Gallate Against Injury Induced by Hydroxyl Radical in Hippocampal Neuronsin vitro" @default.
- W2377173871 hasPublicationYear "2005" @default.
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