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- W2377185911 abstract "AIM To observe the effect of activated charcoal nano-particles(ACN) combination with cisplatin on the anti-cancer action of cisplatin and the immune function of the mice with cancer.METHODS Flat plate clone formation was adopted to evaluate the effect of ACN on the inhibitory action of cisplatin on clone formation of BGC823 cells.The effect of ACN on the inhibitory action of cisplatin on tumor growth was evaluated by constructing S180 carcinoma,H22 hepatoma transplantation tumor model.ELISA was used to evaluate the effect of ACN on IgG level in the culture supernatant of spleen cells.Flow cytometry was used to evaluate the T cell subpopulation of spleen cells.RESULTS ACN had an obvious synergistic effect on the inhibitory action of cisplatin on clone formation of BGC823 cells and on the growth of S180 carcinoma and H22 hepatoma.ACN obviously raised the level of IgG in the culture supernatant of spleen cells,and also heightened the CD4+ T cell percentage,decreased the CD8+ percentage,thereby obviously heightened the CD4+/CD8+ ratio.CONCLUSION ACN can enhance the anti-cancer action of cisplatin and improve the immune function of the mice with cancer." @default.
- W2377185911 created "2016-06-24" @default.
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- W2377185911 date "2008-01-01" @default.
- W2377185911 modified "2023-09-25" @default.
- W2377185911 title "Effects of activated charcoal nano-particles on anti-cancer action of cisplatin" @default.
- W2377185911 hasPublicationYear "2008" @default.
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