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- W2377187718 abstract "Objective To compare the effect of mild hypothermia versus normathermia on the outcome of 428 severe traumatic brain injured patients with severe cerebral contusion and intracranial hypertension ( GCS≤ 8 ). Methods At 6 medical centers, 428 patients with an admission Glasgow Coma Scale score of 8 or less were randomly divided into two groups: mild hypothermia 32 ℃-35 ℃ group (n =210) ,and normathermia (37 ±0.5)℃ group (n = 218). Results According to the glasgow outcome scale at 6 months follow-up, 75 cases got good recovery (35. 7% ) , 32 had moderate deficit (15. 2% ) , 50 severe deficits (23. 8% ) , 7 persistent vegetative status (3.3% ) and 46 were dead (21.9% ) in mild hypothermia group. However, only 56 cases got good recovery (25.7% ) , 25 had moderate deficit (11.5% ) , 58 severe deficits (26.6% ) , 8 persistent vegetative status (3. 7% ) and 71 were dead (32. 6% ) in normathermia group (P 0. 05). Intracranial pressure decreased faster and less in mild hypothermia group than in normathermia group (P0.05). Furthermore, the incidence of stress ulcer and epilepsy in mild hypothermia group was lower than those in normathermia group ( P 0. 05) . However, the incidence of pulmonary infection, intracranial infection and cardiac arrhythmia was not significantly different between two groups (P0.05). Conclusion Mlid hypothermia significantly improves the outcome of severe traumatic brain injured patients with severe cerebral contusion and intracranial hypertension without significant complications." @default.
- W2377187718 created "2016-06-24" @default.
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- W2377187718 date "2005-01-01" @default.
- W2377187718 modified "2023-09-25" @default.
- W2377187718 title "Multicenter Prospective Randomized Controlled Study of Efficacy of Mild Hypothermia for Severe Traumatic Brain Injured Patients with Intracranial Hypertension" @default.
- W2377187718 hasPublicationYear "2005" @default.
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