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- W2377187940 abstract "AIM:To investigate the medical SiO2 nanoparticles induced cytotoxicity and its mechanism on normal human lung cells (MRC-5 cells) in vitro.METHODS:The MRC-5 cells were exposed with different concentrations of SiO2 nanoparticles for 48 h.The cell survival rate was tested by MTT assay and the cell morphological changes were observed with HE staining.The activities of reactive oxygen species (ROS),glutathione (GSH) and superoxide dismutase (SOD) were determined to evaluate the oxidative damage after SiO2 exposure.RESULTS:Exposure with high concentrations above 0.4 mg/mL and 1.0 mg/mL of 21.6 nm and 48.6 nm SiO2 nanoparticles decreased the cell survival rate in a dose-dependent manner.The median inhibitory concentrations (IC50) were 0.8 mg/mL and 1.9 mg/mL respectively.Morphological observation revealed cell shrinkage and nuclear condensation after exposure.The reduced GSH content as well as SOD activity were decreased in SiO2 nanoparticles exposed cells than that of control.CONCLUSION:Medical SiO2 nanoparticles exposure resultes in a dose-dependent cytotoxicity in cultured MRC-5 cells that was associated with increased oxidative stress." @default.
- W2377187940 created "2016-06-24" @default.
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- W2377187940 date "2009-01-01" @default.
- W2377187940 modified "2023-09-24" @default.
- W2377187940 title "Oxidative lesions induced by medical SiO_2 nanoparticles on normal human lung cells" @default.
- W2377187940 hasPublicationYear "2009" @default.
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