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- W2377192455 abstract "[Objective] To establish a rat model of pulmonary hypertension induced by left to right shunt and reflecting of inflammatory effects. [Methods] Abdominal aorta and inferior vena cava shunting was produced in rats, intravenous injection of ferric chloride (0.6%, 0.2 mL/100 g BW) 2 times 1 week were given to rats of the shunt and inflammation group. Pulmonary artery mean pressure(PAMP) of each rat was measured by using a right cardiac catheterization procedure. The radio of right ventricular mass to left ventricular plus septal mass (RV/LV+S) was detected. The structural changes in pulmonary arteries were observed. [Results] PAMP, RV/LV+S and PASMCH were significantly increased in rats affected by inflammation. [Conclusion] The model of pulmonary hypertension by shunt and intravenous injection of ferric chloride can be used to study the roles of inflammation playing in the pathogenesis of pulmonary hypertension." @default.
- W2377192455 created "2016-06-24" @default.
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- W2377192455 date "2005-01-01" @default.
- W2377192455 modified "2023-09-24" @default.
- W2377192455 title "Reproduction of pulmonary hypertension model in rat with shunt and inflammation" @default.
- W2377192455 hasPublicationYear "2005" @default.
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