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- W2377211698 abstract "Objective To study The protective roles of chloropazine (CPZ) and nimodipine (NIMO) on cochlear damage by overdose of sodium salicylate in the guinea pig. Methods Forty-eight healthy guinea pigs were divided into four groups(group A,B,C and D). The threshold and latencies of auditory brainstem response(ABR) were measured at the second,forth,sixth,eighth and tenth day,and before these measures the sodium salicylate, CPZ and NIMO were given to the guinea pigs. The contents of PGIlα in cochlear tissues was measured by radioimmunoassay. The contents of NO in plasma was measured by colorimetric method. Results ①The threshold of ABR in group B, C and D were remarkably higher than group A at the second,forth and sixth day after the drugs were given. But at the forth,sixth,eighth and tenth day,comparing with group B.the threshold of ABR in group C and D were decreased markedly (P 0. 05). ②The latencies of ABR I wave in group B, C and D were remarkablely longer than group A(P0.05) ,and these changes were specifically remarkable in group B. at the eighth, tenth day after the drugs were given. The latencies of ABR Ⅰ wave in group C and D were remarkably shorter than group B(P 0. 05).③The contents of PGI1α in cochlear tissues in group B were decreased markedly(P0. 001) in comparison with group A,C and D. The content of NO in plasma in groupB was remarkablly loner than group A and C. Conclusion The results suggest that administration of CPZ and NIMO facilitates the recovery of cochlear hearing and reduces damage to hair cells after taking the overdose of sodium salicylate." @default.
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- W2377211698 date "2003-01-01" @default.
- W2377211698 modified "2023-09-25" @default.
- W2377211698 title "The Protective Roles of Chloropazine and Nimodipine on Cochlear Damage by Overdose of Sodium Salicylate in the Guinea Pig" @default.
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