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- W2377237884 abstract "AIM : To explore the effects on prostaglandin E-2 and cyclooxygenase-2 mRNA expression of testicular spermatogenic cells in adult rats exposed to di(2-ethylhexyl) phthalate(DEHP).METHODS : 40 male Sprague-Dauley rats were divided into four groups in random: normal control group and 3 groups exposed to DEHP at the dose of 100,200 or 500 mg/kg bodyweight per day by gavage respectively.One month later,the rats were sacrificed.The expression of testicular prostaglandin E-2 was measured by ELISA.The expression level and location of cyclooxygenase-2 and cyclooxygenase-2 mRNA in testicular tissue were detected by immunohistochemistry and RT-PCR,respectively. RESULTS :The expression levels of prostaglandin E-2 and cyclooxygenase-2 of testicular tissue decreased in 3 groups compared with normal control group,cyclooxygenase-2 was mainly expressed in spermatogonia.CONCLUSION : DEHP can damage spermatogenic cells of adult mice,the down-regulating expression of cyclooxygenase-2 mRNA may be involved in it." @default.
- W2377237884 created "2016-06-24" @default.
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- W2377237884 date "2011-01-01" @default.
- W2377237884 modified "2023-09-28" @default.
- W2377237884 title "Effects of di(2-ethylhexyl) phthalate on the prostaglandin E-2 levels and cyclooxygenase-2 mRNA expression of testicular tissue in adult rats" @default.
- W2377237884 hasPublicationYear "2011" @default.
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