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- W2377242810 abstract "Purpose Purpose To investigate the molecular mechanism of the preventive effects of astragalus polysaccharide(APS) on the onset of type 1 diabetes mellitus (DM) in non-obese diabetic (NOD) mice. Methods Twenty NOD mice were divided into two groups, treated with APS and NS, respectively. Blood glucose were measured, and the ultrastructure of islet beta cells was also observed with electron microscope. The mRNA expression of Fas, i-NOS, Bcl-2 and SOD in islet cells of two groups was tested with RT-PCR. Results Compared with the control group, the incidence of DM in APS group was lower (APS group:3/10,30%; NS group:9/10, 90%), and the onset of illness was postponed [APS group:(26.25±5.68) weeks,NS group (21.8±6.78) weeks, P0.05]. Ultrastructure of islets was well protected in APS group. There were integrity of cell membrane and karyotheca, increase of secretory granules, no increase of mitochondria or dilataltion of endoplasmic reticulum, and no vacuoles. As compared to NS group, the mRNA expression of Fas, iNOS was lower in islet cells of APS group, while the mRNA expression of Bcl-2, SOD was higher in APS group. Conclusions Astragalus polysaccharide decreases the incidence of type 1 DM in NOD mice by correcting the imbalance of oxidation/ apoptosis related cytokines." @default.
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- W2377242810 date "2007-01-01" @default.
- W2377242810 modified "2023-09-22" @default.
- W2377242810 title "Effects of astragalus polysaccharides on ultrastructure and oxidation/apoptosis related cytokines' gene expression of non-obese diabetic mice's islets" @default.
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