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- W2377243223 abstract "AIM: To investigate the evaluation method of left ventricular diastolic function and myocardial hypertrophy induced by pressure overload in rats.METHODS: Male Sprague-Dawley rats were subject to left ventricular pressure overload by transverse aortic constriction(TAC).Cardiac structure and diastolic function were evaluated by echocardiography,hemodynamic analysis and examination of hydroxyproline concentration in the myocardial tissues.RESULTS: Compared with the sham-operated controls,left ventricular wall dimension in diastole significantly increased in the rats 3 weeks after TAC [anterior wall:(1.71±0.11) mm vs(1.43±0.06) mm,P0.01;posterior wall:(1.78±0.03) mm vs(1.44±0.02) mm,P0.01].Left ventricular early diastolic posterior wall motion velocity(E′) significantly decreased in the rats 3 weeks after TAC[(52.1±0.8) mm·s-1 vs(63.8±1.5) mm·s1,P0.01],and was much lower than that in the rats 6 weeks after TAC.Left ventricular mass to tibia length in TAC rats was much higher than that in sham-operated controls [3 weeks after TAC:(19.6±1.1) mg·mm-1 vs(14.8±0.6) mg·mm-1,P0.01;6 weeks after TAC:(23.2±0.9) mg·mm-1 vs(15.6±0.7) mg·mm-1,P0.01].The ratio of maximum rate of degression of left ventricular pressure(dp/dtmin) to left ventricular systolic pressure(dp/dtmin/LVSP) started to decrease in TAC rats in the 3rd week(48.9±5.9 vs 63.5±9.9) and significantly decreased in TAC rats in the 6th week as compared with sham-operated controls(35.4±4.0 vs 54.4±2.9,P0.01).Sirius red-stained collagen in cardiac interstitium,especially around the blood vessels,was increased in TAC rats.Six weeks after TAC,a significant increase in the content of myocardial hydroxyproline[(465.3±17.3) μg vs(351.4±8.2) μg,P0.05] was observed.CONCLUSION: The early diastolic posterior wall motion velocity(E′) detected by tissue Doppler imaging is a sensitive indicator of diastolic dysfunction at the early stage of myocardial remodeling induced by pressure overload in rats." @default.
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- W2377243223 date "2011-01-01" @default.
- W2377243223 modified "2023-09-25" @default.
- W2377243223 title "Evaluation of left ventricular diastolic dysfunction at the early stage of pressure overload-induced myocardial remodeling in rats" @default.
- W2377243223 hasPublicationYear "2011" @default.
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